Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy.

ABSTRACT:

Background

Asthma is a common respiratory disease that is characterized by bronchial hyperresponsiveness and airway obstruction due to chronic airway inflammation. Atopic asthma is a typical IgE-mediated disease in which the enhanced production of IgE is driven by the activation of Th2 cells, which release a distinct pattern of cytokines, including interleukin 4 (IL4) and IL3, in response to specific antigen presentation. To evaluate the methylation status of the whole genomes of bronchial mucosa tissues from subjects who lacked or had sensitization to Dermatophagoides farina (Df) and Dermatophagoides pteronyssinus (Dp).

Methods

The genome-wide DNA methylation levels in the bronchial mucosa tissues of atopic asthmatics (N=10), non-atopic asthmatics (N=7), and normal controls

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC3616917 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature