Pathogenic characteristics of three genotype II porcine reproductive and respiratory syndrome viruses isolated from China.

ABSTRACT:

Background

We examined differences in pathogenicity in pigs from China that had been experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV).

Methods

We compared pathogenic characteristics of a field isolate (GX-1/2008F), two PRRSV isolates (HN-1/2008, YN-1/2008) propagated in cells, and GX-1/2008F that had been propagated in cells (GX-1/2008). The clinical courses, along with humoral and cell-mediated responses, were monitored for 21 days post-infection (DPI). Animals were sacrificed and tissue samples used for gross pathological, histopathological and ultrastructure examination.

Results

At 2-3 DPI, animals infected with cell-propagated viruses exhibited signs of coughing, anorexia and fever. However their rectal temperature did not e

SUBMITTER: Shang Y 

PROVIDER: S-EPMC3616938 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature