Genome-wide associations of signaling pathways in glioblastoma multiforme.

ABSTRACT:

Background

eQTL analysis is a powerful method that allows the identification of causal genomic alterations, providing an explanation of expression changes of single genes. However, genes mediate their biological roles in groups rather than in isolation, prompting us to extend the concept of eQTLs to whole gene pathways.

Methods

We combined matched genomic alteration and gene expression data of glioblastoma patients and determined associations between the expression of signaling pathways and genomic copy number alterations with a non-linear machine learning approach.

Results

Expectedly, over-expressed pathways were largely associated to tag-loci on chromosomes with signature alterations. Surprisingly, tag-loci that were associated to under-expressed pathways were large

SUBMITTER: Wuchty S 

PROVIDER: S-EPMC3616958 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature