Cooperative adaptive responses in gene regulatory networks with many degrees of freedom.

ABSTRACT: Cells generally adapt to environmental changes by first exhibiting an immediate response and then gradually returning to their original state to achieve homeostasis. Although simple network motifs consisting of a few genes have been shown to exhibit such adaptive dynamics, they do not reflect the complexity of real cells, where the expression of a large number of genes activates or represses other genes, permitting adaptive behaviors. Here, we investigated the responses of gene regulatory networks containing many genes that have undergone numerical evolution to achieve high fitness due to the adaptive response of only a single target gene; this single target gene responds to changes in external inputs and later returns to basal levels. Despite setting a single target, most genes showed ada

SUBMITTER: Inoue M 

PROVIDER: S-EPMC3616990 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature