Frequency shifts in the anterior default mode network and the salience network in chronic pain disorder.

ABSTRACT:

Background

Recent functional imaging studies on chronic pain of various organic etiologies have shown significant alterations in both the spatial and the temporal dimensions of the functional connectivity of the human brain in its resting state. However, it remains unclear whether similar changes in intrinsic connectivity networks (ICNs) also occur in patients with chronic pain disorder, defined as persistent, medically unexplained pain.

Methods

We compared 21 patients who suffered from chronic pain disorder with 19 age- and gender-matched controls using 3T-fMRI. All neuroimaging data were analyzed using both independent component analysis (ICA) and power spectra analysis.

Results

In patients suffering from chronic pain disorder, the fronto-insular 'salience' network

SUBMITTER: Otti A 

PROVIDER: S-EPMC3616999 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature