Divergence of mammalian higher order chromatin structure is associated with developmental loci.

ABSTRACT: Several recent studies have examined different aspects of mammalian higher order chromatin structure - replication timing, lamina association and Hi-C inter-locus interactions - and have suggested that most of these features of genome organisation are conserved over evolution. However, the extent of evolutionary divergence in higher order structure has not been rigorously measured across the mammalian genome, and until now little has been known about the characteristics of any divergent loci present. Here, we generate a dataset combining multiple measurements of chromatin structure and organisation over many embryonic cell types for both human and mouse that, for the first time, allows a comprehensive assessment of the extent of structural divergence between mammalian genomes. Comparison o

SUBMITTER: Chambers EV 

PROVIDER: S-EPMC3617018 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature