Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naive acromegaly.

ABSTRACT: Patients with active untreated acromegaly show mild to moderate neurocognitive disorders that are associated to chronic exposure to growth hormone (GH) and insulin-like growth factor (IGF-I) hypersecretion. However, it is unknown whether these disorders improve after controlling GH/IGF-I hypersecretion. The aim of this study was to compare neurocognitive functions of patients who successfully underwent GH-secreting adenoma transsphenoidal surgery (cured patients) with patients with naive acromegaly. In addition, we wanted to determine the impact of different clinical and biochemical variables on neurocognitive status in patients with active disease and after long-term cure. A battery of six standardized neuropsychological tests assessed attention, memory and executive functioning. In addit

SUBMITTER: Martin-Rodriguez JF 

PROVIDER: S-EPMC3617159 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature