Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes.

ABSTRACT: Glomerular podocytes are highly differentiated epithelial cells that are key components of the kidney filtration units. Podocyte damage or loss is the hallmark of nephritic diseases characterized by severe proteinuria. Recent studies implicate that hormones including glucocorticoids (ligand for glucocorticoid receptor) and vitamin D3 (ligand for vitamin D receptor) protect or promote repair of podocytes from injury. In order to elucidate the mechanisms underlying hormone-mediated podocyte-protecting activity from injury, we carried out microarray gene expression studies to identify the target genes and corresponding pathways in response to these hormones during podocyte differentiation. We used immortalized human cultured podocytes (HPCs) as a model system and carried out in vitro differen

SUBMITTER: Cheng X 

PROVIDER: S-EPMC3617172 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature