MH²c: Characterization of major histocompatibility <i>α</i>-helices - an information criterion approach.

ABSTRACT: Major histocompatibility proteins share a common overall structure or peptide binding groove. Two binding groove domains, on the same chain for major histocompatibility class I or on two different chains for major histocompatibility class II, contribute to that structure that consists of two α-helices ("wall") and a sheet of eight anti-parallel beta strands ("floor"). Apart from the peptide presented in the groove, the major histocompatibility α-helices play a central role for the interaction with the T cell receptor. This study presents a generalized mathematical approach for the characterization of these helices. We employed polynomials of degree 1 to 7 and splines with 1 to 2 nodes based on polynomials of degree 1 to 7 on the α-helices projected on their principal c

SUBMITTER: Hischenhuber B 

PROVIDER: S-EPMC3617674 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature