Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats.

ABSTRACT:

Background

The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats.

Methods

Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). The Unavoidable Aversive Light Stimulus (UALST) and the Forced Swimming Test (FST) were used to evaluate the antidepressant-like effects of KO. Imipramine (IMIP) was used as the antidepressant reference substance.

Results

After 7 weeks of KO intake, both males and females treated with KO were significantly better in discriminating between the active and the inactive levers in the ALSAT from day 1 of training (p<0.01). Both KO and IMIP prevented resignation/depression on the third day in the UALST. Similarly, a shorter immobility time was observed fo

SUBMITTER: Wibrand K 

PROVIDER: S-EPMC3618203 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature