Trans-species activity of a nonself recognition domain.

ABSTRACT:

Background

The ability to distinguish nonself from self is a fundamental characteristic of biological systems. In the filamentous fungus Neurospora crassa, multiple incompatibility genes mediate nonself recognition during vegetative growth. One of these genes, un-24, encodes both nonself recognition function and the large subunit of a type I ribonucleotide reductase, an evolutionarily conserved enzyme that is essential for the conversion of NDP precursors into dNDPs for use in DNA synthesis. Previous studies have shown that co-expression of the two allelic forms of un-24, Oakridge (OR) and Panama (PA), in the same cell results in cell death.

Results

We identify a 135 amino acid nonself recognition domain in the C-terminus region of UN-24 that confers an incompatibility-like

SUBMITTER: Smith RP 

PROVIDER: S-EPMC3618301 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature