A detailed molecular analysis of complete bovine leukemia virus genomes isolated from B-cell lymphosarcomas.

ABSTRACT: It is widely accepted that the majority of cancers result from multiple cellular events leading to malignancy after a prolonged period of clinical latency, and that the immune system plays a critical role in the control of cancer progression. Bovine leukemia virus (BLV) is an oncogenic member of the Retroviridae family. Complete genomic sequences of BLV strains isolated from peripheral blood mononuclear cells (PBMC) from cattle have been previously reported. However, a detailed characterization of the complete genome of BLV strains directly isolated from bovine tumors is much needed in order to contribute to the understanding of the mechanisms of leukemogenesis induced by BLV in cattle. In this study, we performed a molecular characterization of BLV complete genomes from bovine B-cell lymp

SUBMITTER: Moratorio G 

PROVIDER: S-EPMC3618307 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature