The structure of a gene co-expression network reveals biological functions underlying eQTLs.

ABSTRACT: What are the commonalities between genes, whose expression level is partially controlled by eQTL, especially with regard to biological functions? Moreover, how are these genes related to a phenotype of interest? These issues are particularly difficult to address when the genome annotation is incomplete, as is the case for mammalian species. Moreover, the direct link between gene expression and a phenotype of interest may be weak, and thus difficult to handle. In this framework, the use of a co-expression network has proven useful: it is a robust approach for modeling a complex system of genetic regulations, and to infer knowledge for yet unknown genes. In this article, a case study was conducted with a mammalian species. It showed that the use of a co-expression network based on partial co

SUBMITTER: Villa-Vialaneix N 

PROVIDER: S-EPMC3618335 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature