Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination.

ABSTRACT: Activation-induced cytidine deaminase (AID) was first described as the triggering enzyme of the B-cell-specific reactions that edit the immunoglobulin genes, namely somatic hypermutation, gene conversion, and class switch recombination. Over the years, AID was also detected in cells other than lymphocytes, and it has been assigned additional roles in the innate defense against transforming retroviruses, in retrotransposition restriction and in DNA demethylation. Notably, AID expression was found in germline tissues, and in heterologous systems it can induce the double-strand breaks required for the initiation of meiotic recombination and proper gamete formation. However, because AID-deficient mice are fully fertile, the molecule is not essential for meiosis. Thus, the remaining question th

SUBMITTER: Cortesao CS 

PROVIDER: S-EPMC3618351 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature