Ontology highlight
ABSTRACT:
SUBMITTER: Copin JC
PROVIDER: S-EPMC3618389 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Copin Jean-Christophe JC da Silva Rafaela F RF Fraga-Silva Rodrigo A RA Capettini Luciano L Quintao Silvia S Lenglet Sébastien S Pelli Graziano G Galan Katia K Burger Fabienne F Braunersreuther Vincent V Schaller Karl K Deruaz Maud M Proudfoot Amanda E AE Dallegri Franco F Stergiopulos Nikolaos N Santos Robson A S RA Gasche Yvan Y Mach François F Montecucco Fabrizio F
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20121219 4
Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of the CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactivity and related neutrophilic inflammation in two mouse models of carotid atherosclerosis and ischemic stroke, respectively. In the first model, the chronic treatment with Evasin-3 as compared with Vehicle (phosphate-buffered saline (PBS)) was i ...[more]