Heteroatom analogues of hydrocodone: synthesis and biological activity.

ABSTRACT: Heteroatom analogues of hydrocodone, in which the N-methyl functionality was replaced with oxygen, sulfur, sulfoxide, and sulfone, were prepared by a short sequence from the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone was also prepared. The compounds were tested for receptor binding and revealed moderate levels of activity for the sulfone analogue of hydrocodone.

SUBMITTER: Giacometti RD 

PROVIDER: S-EPMC3618612 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature