Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma.

ABSTRACT:

Background

Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, has been implicated in the initiation and progression of cancers. We tested whether YWHAZ acted as a cancer-promoting gene through its activation/overexpression in gastric cancer (GC).

Methods

We analysed 7 GC cell lines and 141 primary tumours, which were curatively resected in our hospital between 2001 and 2003.

Results

Overexpression of the YWHAZ protein was frequently detected in GC cell lines (six out of seven lines, 85.7%) and primary tumour samples of GC (72 out of 141 cases, 51%), and significantly correlated with larger tumour size, venous and lymphatic invasion, deeper tumour depth, and higher pathological stage and recurrence rate. Patients with YWH

SUBMITTER: Nishimura Y 

PROVIDER: S-EPMC3619260 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature