Common genetic variants in the 9p21 region and their associations with multiple tumours.

ABSTRACT:

Background

The chromosome 9p21.3 region has been implicated in the pathogenesis of multiple cancers.

Methods

We systematically examined up to 203 tagging SNPs of 22 genes on 9p21.3 (19.9-32.8 Mb) in eight case-control studies: thyroid cancer, endometrial cancer (EC), renal cell carcinoma, colorectal cancer (CRC), colorectal adenoma (CA), oesophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma and osteosarcoma (OS). We used logistic regression to perform single SNP analyses for each study separately, adjusting for study-specific covariates. We combined SNP results across studies by fixed-effect meta-analyses and a newly developed subset-based statistical approach (ASSET). Gene-based P-values were obtained by the minP method using the Adaptive Rank Truncated

SUBMITTER: Gu F 

PROVIDER: S-EPMC3619272 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature