Toward a unified physical model of nucleosome patterns flanking transcription start sites.

ABSTRACT: Recent genome-wide maps of nucleosome positions in different eukaryotes revealed patterns around transcription start sites featuring a nucleosome-free region flanked by a periodic modulation of the nucleosome density. For Saccharomyces cerevisiae, the average in vivo pattern was previously shown to be quantitatively described by a "nucleosome gas" model based on the statistical positioning mechanism. However, this simple physical description is challenged by the fact that the pattern differs quantitatively between species and by recent experiments that appear incompatible with statistical positioning, indicating important roles for chromatin remodelers. We undertake a data-driven search for a unified physical model to describe the nucleosome patterns of 12 yeast species and also consider a

SUBMITTER: Mobius W 

PROVIDER: S-EPMC3619296 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature