An algorithmic approach for breakage-fusion-bridge detection in tumor genomes.

ABSTRACT: Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids. When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as fold-back inversions where duplicated segments are arranged head-to-head. These structural variations can then drive tumorigenesis. BFB can be observed in progress using cytogenetic techniques, but generally BFB must be inferred from data such as microarrays or sequencing collected after BFB has ceased. Making correct inferences from this data is not straightforward, particularly given the complexity of some cancer genomes and BFB's ability to generate a wide range of rearrangement patterns. Here

SUBMITTER: Zakov S 

PROVIDER: S-EPMC3619374 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature