Systems pharmacology: network analysis to identify multiscale mechanisms of drug action.

ABSTRACT: Systems approaches have long been used in pharmacology to understand drug action at the organ and organismal levels. The application of computational and experimental systems biology approaches to pharmacology allows us to expand the definition of systems pharmacology to include network analyses at multiple scales of biological organization and to explain both therapeutic and adverse effects of drugs. Systems pharmacology analyses rely on experimental "omics" technologies that are capable of measuring changes in large numbers of variables, often at a genome-wide level, to build networks for analyzing drug action. A major use of omics technologies is to relate the genomic status of an individual to the therapeutic efficacy of a drug of interest. Combining pathway and network analyses, pharm

SUBMITTER: Zhao S 

PROVIDER: S-EPMC3619403 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature