A U-shaped relationship between haematocrit and mortality in a large prospective cohort study.

ABSTRACT:

Background

Only a limited number of studies have investigated the correlation between haematocrit (HCT) and mortality in the general population, and few of those studies have had data on a wide range of low and high levels of HCT. We investigated the association between baseline HCT and mortality in a prospective cohort study of 49,983 adult subjects in Iran with a broad spectrum of HCT values.

Methods

Data on socio-demographic and life-style factors, past medical history, and levels of HCT were collected at enrollment. During a mean follow-up of 5 years (follow-up success rate ~99%), 2262 deaths were reported. Cox proportional hazards regression models were used to estimate hazard ratios and corresponding 95% confidence intervals.

Results

There was a U-shaped relatio

SUBMITTER: Boffetta P 

PROVIDER: S-EPMC3619954 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature