Hemodynamic responses to visual stimulation in children with sickle cell anemia.

ABSTRACT: Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12.4  ±  0.7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11  ±  1.0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the

SUBMITTER: Zou P 

PROVIDER: S-EPMC3620037 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature