Genetic variants in the NOTCH4 gene influence the clinical features of migraine.

ABSTRACT:

Background

Recent studies suggested an important role for vascular factors in migraine etiopathogenesis. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The aim of this study was to test the hypothesis that polymorphisms of the NOTCH4 gene would modify the occurrence and the clinical features of migraine.

Findings

Using a case-control strategy, we genotyped 239 migraine patients and 264 controls for three different non-synonymous polymorphisms (T320A, G835V, R1346P) of the NOTCH4 gene and for the (CTG) n-encoding polyleucine polymorphism in exon 1. Although the analyzed polymorphisms resulted not associated with migraine, the clinical characteristics of our patients were significantly influenced by th

SUBMITTER: Rubino E 

PROVIDER: S-EPMC3620438 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature