Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.

ABSTRACT:

Background and objective

Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an individual's susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise estimation of the associations between eight polymorphisms in the ESR1 gene and endometrial cancer risk.

Methods

A literature search of PubMed, Embase, Web of Science and China Biology Medicine (CBM) databases was conducted on publications published before November 1(st), 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using the STATA 12.0 software.

Results

Thirteen case-control studies w

SUBMITTER: Zhou X 

PROVIDER: S-EPMC3620469 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature