Genome-wide analysis of human hotspot intersected genes highlights the roles of meiotic recombination in evolution and disease.

ABSTRACT:

Background

Meiotic recombination events are not randomly located, but rather cluster at hotspot regions. Recently, the fine-scale mapping of genome-wide human recombination hotspots was performed. Here, we systematically analyzed the evolutionary and disease-associated features of hotspots that overlapped with protein-coding genes.

Results

In this study, we defined hotspot intersected genes as HI genes. We found that HI genes were prone to be located in the extracellular part and were functionally enriched in cell-to-cell communication. Tissue-specific genes and secreted protein encoding genes were overrepresented in HI genes, while housekeeping genes were underrepresented. Compared to slowly evolving housekeeping genes and random genes with lower recombination rates, HI gen

SUBMITTER: Zhou T 

PROVIDER: S-EPMC3620679 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature