Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women.

ABSTRACT:

Objective

To relate serum leptin levels to prevalent and incident radiographic knee osteoarthritis (OA) and to determine if patterns of change in longitudinal serum leptin measures differ by knee OA status over a 10-year period.

Methods

Participants in the Michigan Study of Women's Health Across the Nation underwent bilateral knee radiographs at baseline and followup visits 2, 4, and 11 for ascertainment of knee OA status (Kellgren/Lawrence score ≥2). Serum leptin measures were available from baseline and followup visits 1 and 3-7.

Results

The baseline prevalence of knee OA (mean age 46 years) was 18%; the 2-year incidence of knee OA at followup visits 2 and 4 was 18% and 14%, respectively. Serum leptin levels were associated with prevalent and incident knee OA. A 5 n

SUBMITTER: Karvonen-Gutierrez CA 

PROVIDER: S-EPMC3620918 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature