Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.

ABSTRACT: We present an analysis of over 1,100 of the approximately 10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics and biology are covered. First, the basic features of the genome, including the automated assembly, gene calls, and global gene analyses are summarized. The second section covers components of the centromere and kinetochore complexes, chromatin assembly and modification, and transcription and translation initiation factors. The third area discusses genome defense mechanisms, including repeat induced point mutation, quelling and meiotic silencing, and DNA repair and recombination. In the fourth section, topics relevant to metabolism and transport include extracellular digestion; membrane trans

SUBMITTER: Borkovich KA 

PROVIDER: S-EPMC362109 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature