Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates.

ABSTRACT:

Background

Formaldehyde is an air pollutant present in both indoor and outdoor atmospheres. Because of its ubiquitous nature, it is imperative to understand the mechanisms underlying formaldehyde-induced toxicity and carcinogenicity. MicroRNAs (miRNAs) can influence disease caused by environmental exposures, yet miRNAs are understudied in relation to formaldehyde. Our previous investigation demonstrated that formaldehyde exposure in human lung cells caused disruptions in miRNA expression profiles in vitro.

Objectives

Using an in vivo model, we set out to test the hypothesis that formaldehyde inhalation exposure significantly alters miRNA expression profiles within the nasal epithelium of nonhuman primates.

Methods

Cynomolgus macaques were exposed by inhalation to appr

SUBMITTER: Rager JE 

PROVIDER: S-EPMC3621188 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature