Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine.

ABSTRACT:

Background

Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in association studies. Other genes might also play roles in arsenic metabolism and excretion.

Objective

We evaluated genetic determinants of urine arsenic metabolites in American Indian adults from the Strong Heart Study (SHS).

Methods

We evaluated heritability of urine arsenic metabolites [percent inorganic arsenic (%iAs), percent monomethylarsonate (%MMA), and percent dimethylarsinate (%DMA)] in 2,907 SHS participants with urine arsenic measurements and at least one relative within the cohort. We conducted a preliminary linkage analysis in a subset of 487 participants with available genotypes on approximately 400 short tandem repeat markers using a general pedigree vari

SUBMITTER: Tellez-Plaza M 

PROVIDER: S-EPMC3621197 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature