Human health effects of trichloroethylene: key findings and scientific issues.

ABSTRACT:

Background

In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years.

Objectives

We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA's toxicological review.

Methods

In this assessment we synthesized and characterized thousands of epidemiologic, experimental animal, and mechanistic studies, and addressed several key scientific issues through modeling of TCE toxicokinetics, meta-analyses of epidemiologic studies, and analyses of mechanistic data.

Discussion

Toxicokinetic modeling aided in characterizing the toxicological role

SUBMITTER: Chiu WA 

PROVIDER: S-EPMC3621199 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature