The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling.

ABSTRACT: The development of a functional tissue requires coordination of the amplification of progenitors and their differentiation into specific cell types. The molecular basis for this coordination during myotome ontogeny is not well understood. Dermomytome progenitors that colonize the myotome first acquire myocyte identity and subsequently proliferate as Pax7-expressing progenitors before undergoing terminal differentiation. We show that the dynamics of sonic hedgehog (Shh) signaling is crucial for this transition in both avian and mouse embryos. Initially, Shh ligand emanating from notochord/floor plate reaches the dermomyotome, where it both maintains the proliferation of dermomyotome cells and promotes myogenic differentiation of progenitors that colonized the myotome. Interfering with Shh s

SUBMITTER: Kahane N 

PROVIDER: S-EPMC3621491 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature