Inhibition of Ras-Effector Interaction by Cyclic Peptides.

ABSTRACT: A combinatorial library of 6 × 10⁶ cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.

SUBMITTER: Wu X 

PROVIDER: S-EPMC3621770 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature