Gene expression changes associated with the airway wall response to injury.

ABSTRACT:

Background

Understanding the way in which the airway heals in response to injury is fundamental to dissecting the mechanisms underlying airway disease pathology. As only limited data is available in relation to the in vivo characterisation of the molecular features of repair in the airway we sought to characterise the dynamic changes in gene expression that are associated with the early response to physical injury in the airway wall.

Methodology/principal findings

We profiled gene expression changes in the airway wall using a large animal model of physical injury comprising bronchial brush biopsy in anaesthetised sheep. The experimental design featured sequential studies in the same animals over the course of a week and yielded data relating to the response at 6 hours, and 1

SUBMITTER: Yahaya B 

PROVIDER: S-EPMC3621906 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature