Analysis of the effects of sex hormone background on the rat choroid plexus transcriptome by cDNA microarrays.

ABSTRACT: The choroid plexus (CP) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF), the blood-CSF barrier, that are the main site of production and secretion of CSF. Sex hormones are widely recognized as neuroprotective agents against several neurodegenerative diseases, and the presence of sex hormones cognate receptors suggest that it may be a target for these hormones. In an effort to provide further insight into the neuroprotective mechanisms triggered by sex hormones we analyzed gene expression differences in the CP of female and male rats subjected to gonadectomy, using microarray technology. In gonadectomized female and male animals, 3045 genes were differentially expresse

SUBMITTER: Quintela T 

PROVIDER: S-EPMC3622009 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature