Covariate adjustment in estimating the area under ROC curve with partially missing gold standard.

ABSTRACT: In ROC analysis, covariate adjustment is advocated when the covariates impact the magnitude or accuracy of the test under study. Meanwhile, for many large scale screening tests, the true condition status may be subject to missingness because it is expensive and/or invasive to ascertain the disease status. The complete-case analysis may end up with a biased inference, also known as "verification bias." To address the issue of covariate adjustment with verification bias in ROC analysis, we propose several estimators for the area under the covariate-specific and covariate-adjusted ROC curves (AUCx and AAUC). The AUCx is directly modeled in the form of binary regression, and the estimating equations are based on the U statistics. The AAUC is estimated from the weighted average of AUCx over the

SUBMITTER: Liu D 

PROVIDER: S-EPMC3622116 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature