Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?

ABSTRACT:

Background and purpose

Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS.

Methods

Meta-analyses of the associations between the 11 MI-associated SNPs and IS were performed using 6865 cases and 11 395 control subjects recruited from 9 studies. SNPs were either genotyped directly or imputed; in a few cases a surrogate SNP in high linkage disequilibrium was chosen. Logistic regression was performed withi

SUBMITTER: Cheng YC 

PROVIDER: S-EPMC3622211 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature