Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer.

ABSTRACT: The tumor immunosurveillance hypothesis describes a process by which the immune system recognizes and suppresses the growth of transformed cancer cells. A variety of epidemiological and experimental evidence supports this hypothesis. Nevertheless, there are a number of conflicting reports regarding the degree of immune protection conferred, the immune cell types responsible for protection, and the potential contributions of immunosuppressive therapies to tumor induction. The purpose of this study was to determine whether the adaptive immune system actively suppresses tumorigenesis in a Sleeping Beauty (SB) mouse model of cancer. SB transposon mutagenesis was performed in either a wild-type or immunocompromised (Rag2-null) background. Tumor latency and multiplicity were remarkably similar i

SUBMITTER: Rogers LM 

PROVIDER: S-EPMC3622230 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature