Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions.

ABSTRACT:

Objective

To assess the long-term outcome of brain structure in preterm infants, at an average age of 12 years, who received a red blood cell transfusion for anemia of prematurity.

Design

As neonates, this cohort of infants participated in a clinical trial in which they received red blood cell transfusions based on a high pretransfusion hematocrit threshold (liberal group) or a low hematocrit threshold (restricted group). These 2 preterm groups were compared with a group of full-term healthy control children.

Setting

Tertiary care hospital.

Participants

Magnetic resonance imaging scans for 44 of the original 100 subjects were obtained.

Intervention

Liberal vs restricted transfusion.

Main outcome measures

Intracranial volume, total brain tissue, to

SUBMITTER: Nopoulos PC 

PROVIDER: S-EPMC3622941 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature