Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma.

ABSTRACT:

Background

Allergic airway inflammation contributes to the airway remodelling that has been linked to increased obstruction and morbidity in asthma. However, the mechanisms by which allergens contribute to airway remodelling in humans are not fully established. CCL18, chitotriosidase (CHIT1) and YKL-40 are readily detectable in the lungs and contribute to remodelling in other fibrotic diseases, but their involvement in allergic asthma is unclear.

Objective

We hypothesized that CCL18, YKL-40 and CHIT1 bioactivity are enhanced in allergic asthma subjects after segmental allergen challenge and are related to increased pro-fibrotic and Th2-associated mediators in the lungs.

Methods

Levels of CCL18 and YKL-40 protein and chitotriosidase (CHIT1) bioactivity in bronchoalveol

SUBMITTER: Gavala ML 

PROVIDER: S-EPMC3623278 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature