Effect of specific allergen inhalation on serum adiponectin in human asthma.

ABSTRACT:

Background

Adiponectin is associated with asthma. The direction of this association is not known in humans. In mice, this association is bidirectional: allergen inhalation affects serum adiponectin, and exogenous adiponectin administration affects asthma. We sought to evaluate whether allergen inhalation affects serum adiponectin in human asthma.

Methods

This study included eight sensitized subjects with mild asthma and six healthy control subjects. Asthmatic subjects were challenged with inhaled specific allergen (positive allergen skin test), methacholine, and irrelevant allergen (negative allergen skin test). Control subjects were challenged with irrelevant allergen. Sequential serum samples were obtained before and nine times after each challenge. Serum adiponectin- (pri

SUBMITTER: Sood A 

PROVIDER: S-EPMC3623933 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature