Role of selected genetic variants in lung cancer risk in African Americans.

ABSTRACT:

Introduction

Black/white disparities in lung cancer incidence and mortality mandate an evaluation of underlying biological differences. We have previously shown higher risks of lung cancer associated with prior emphysema in African American compared with white patients with lung cancer.

Methods

We therefore evaluated a panel of 1440 inflammatory gene variants in a two-phase analysis (discovery and replication), added top genome-wide association studies (GWAS) lung cancer hits from white populations, and 28 single-nucleotide polymorphisms (SNPs) from a published gene panel. The discovery set (477 self-designated African Americans cases, 366 controls matched on age, ethnicity, and gender) were from Houston, Texas. The external replication set (330 cases and 342 controls) was f

SUBMITTER: Spitz MR 

PROVIDER: S-EPMC3623962 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature