Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.

ABSTRACT: There are multiple identified mechanisms involved in energy metabolism, insulin resistance and adiposity, but there are here-to-fore unsuspected metabolic factors that also influence these processes. Studies in animal models suggest important links between choline/1-carbon metabolism and energy homeostasis. Rodents fed choline deficient diets become hypermetabolic. Mice with deletions in one of several different genes of choline metabolism have phenotypes that include increased metabolic rate, decreased body fat/lean mass ratio, increased insulin sensitivity, decreased ATP production by mitochondria, or decreased weight gain on a high fat diet. In addition, farmers have recognized that the addition of a metabolite of choline (betaine) to cattle and swine feed reduces body fat/lean mass rat

SUBMITTER: Zeisel SH 

PROVIDER: S-EPMC3624053 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature