Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury.

ABSTRACT:

Objective

Develop a non-terminal animal model of acute joint injury that demonstrates clinical and morphological evidence of early post-traumatic osteoarthritis (PTOA).

Methods

An osteochondral (OC) fragment was created arthroscopically in one metacarpophalangeal (MCP) joint of 11 horses and the contralateral joint was sham operated. Eleven additional horses served as unoperated controls. Every 2 weeks, force plate analysis, flexion response, joint circumference, and synovial effusion scores were recorded. At weeks 0 and 16, radiographs (all horses) and arthroscopic videos (OC injured and sham joints) were graded. At week 16, synovium and cartilage biopsies were taken arthroscopically from OC injured and sham joints for histologic evaluation and the OC fragment was removed.<

SUBMITTER: Boyce MK 

PROVIDER: S-EPMC3624059 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature