Amphetamine effects on MATRICS Consensus Cognitive Battery performance in healthy adults.

ABSTRACT:

Background

Cognitive deficits contribute strongly to functional disability in schizophrenia. The cost of identifying and testing candidate procognitive agents is substantial. Conceivably, candidate drugs might be first identified by positive effects on cognitive domains in sensitive subgroups of healthy subjects. Here, we examined whether the MATRICS Consensus Cognitive Battery (MCCB) detected procognitive drug effects in subgroups of healthy individuals.

Methods

The effects of 20 mg amphetamine (AMPH) on MCCB performance were tested in a double-blind, placebo-controlled crossover study of 60 healthy adults. AMPH effects were compared in subgroups of subjects characterized by low vs. high placebo MCCB scores, and by extreme values on personality subscales associated with sch

SUBMITTER: Chou HH 

PROVIDER: S-EPMC3624060 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature