Systemic and local infection routes govern different cellular dissemination pathways during gammaherpesvirus infection in vivo.

ABSTRACT: Human gammaherpesviruses cause morbidity and mortality associated with infection and transformation of lymphoid and endothelial cells. Knowledge of cell types involved in virus dissemination from primary virus entry to virus latency is fundamental for the understanding of gammaherpesvirus pathogenesis. However, the inability to directly trace cell types with respect to virus dissemination pathways has prevented definitive conclusions regarding the relative contribution of individual cell types. Here, we describe that the route of infection affects gammaherpesvirus dissemination pathways. We constructed a recombinant murine gammaherpesvirus 68 (MHV-68) variant harboring a cassette which switches fluorescent markers in a Cre-dependent manner. Since the recombinant virus which was constructed

SUBMITTER: Vidy A 

PROVIDER: S-EPMC3624335 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature