Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes.

ABSTRACT:

Study objectives

To examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years.

Design

Randomized controlled trial with follow-up at 1, 2, and 4 years.

Setting

4 Look AHEAD clinical centers.

Participants

Two hundred sixty-four obese adults with type 2 diabetes and OSA.

Interventions

Intensive lifestyle intervention with a behavioral weight loss program or diabetes support and education.

Measurements

Change in apnea-hypopnea index on polysomnogram.

Results

The intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group

SUBMITTER: Kuna ST 

PROVIDER: S-EPMC3624818 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature