Mirtazapine provokes periodic leg movements during sleep in young healthy men.

ABSTRACT:

Study objectives

Recent evidence suggests that certain antidepressants are associated with an increase of periodic leg movements (PLMS) that may disturb sleep. So far, this has been shown in patients clinically treated for depression and in cross-sectional studies for various substances, but not mirtazapine. It is unclear whether antidepressants induce the new onset of PLMS or only increase preexisting PLMS, and whether this is a general property of the antidepressant or only seen in depressed patients. We report here the effect of mirtazapine on PLMS in young healthy men.

Design

Open-labeled clinical trial (NCT00878540) including a 3-week preparatory phase with standardized food, physical activity, and sleep-wake behavior, and a 10-day experimental inpatient phase with an a

SUBMITTER: Fulda S 

PROVIDER: S-EPMC3624820 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature