Chromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA.

ABSTRACT: The maintenance of genomic integrity is of main importance to the survival and health of organisms which are continuously exposed to genotoxic stress. Cells respond to DNA damage by activating survival pathways consisting of cell cycle checkpoints and repair mechanisms. However, the signal that triggers the DNA damage response is not necessarily a direct detection of the primary DNA lesion. In fact, chromatin defects may serve as initiating signals to activate those mechanisms. If the modulation of chromatin structure could initiate a checkpoint response in a direct manner, this supposes the existence of specific chromatin sensors. p19INK4d, a member of the INK4 cell cycle inhibitors, plays a crucial role in regulating genomic stability and cell viability by enhancing DNA repair. Its expre

SUBMITTER: Ogara MF 

PROVIDER: S-EPMC3625165 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature