Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.

ABSTRACT:

Background

Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association.

Methodology/principal findings

We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found tha

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC3625214 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature